AUTOPLASTIC THYMUS TRANSPLANTS

Autoplastic Thymus Transplants

1. Regeneration of a thymus transplant is characterized by hypertrophy and hyperplasia of the reticulum cells, leading to the formation of small and large atypical Hassall bodies during the early stages. 2. Regeneration is usually complete by the 3rd week, when the newly formed lobules show differentiation into cortical and medullary zones, and typical Hassall bodies appear. 3. Typical Hassall'...

Studies on the Histogenesis of Autoplastic Thymus Transplantations

1. The thymus gland of young rats autotransplants easily when inserted in the muscles of the abdominal wall. 2. Destructive changes take place during the first 48 hours, when regenerative changes set in. 3. The regeneration is usually complete by the 14th day, when the new formed thymic lobules show differentiation into cortical and medullary zones. 4. The small thymic cells arise from the reti...

Morphological and Functional Studies of Fetal Thymus Transplants in Mice

The fetal thymus at 13 days of gestation withstands transplantation and develops normally under the renal capsule of a syngenic host. Distinct differences were observed between the fetal thymus grafts and grafts from neonatal or adult thymus donors. The fetal thymus graft did not undergo the rapid and severe necrosis observed when adult thymus was grafted. Furthermore, when thymuses were transp...

Cellular transplants.

TRANSPLANTATION Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants

1Department of Pediatrics, Duke University Medical Center, Durham, NC; 2Department of Immunology, Duke University Medical Center, Durham, NC; 3Center for Computational Immunology, Duke University Medical Center, Durham, NC; 4Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC; 5Department of Pathology, Duke University Medical Center, Durham, NC; 6Departmen...